Obinutuzumab in Patients With Active

and titles to filter out irrelevant articles, and a third reviewer settled any conflicts. The complete search methodology and results are given in Supplemental Digital Content 1 (see Table S1, http://links.lww.com/AJT/ A224). Inclusion criteria required studies to (1) RCTs evaluating obinutuzumab plus standard therapy versus placebo plus standard therapy, (2) included adults aged 18–75 years with biopsy confirming active lupus nephritis (class III or IV, with or without Class V disease), (3) assessed at least 1 outcome related to complete kidney response, defined by a urinary protein-tocreatinine ratio ,0.5, an eGFR of at least 85% of baseline, and absence of treatment failure, rescue therapy, death or early withdrawal. Exclusion criteria included nonrandomized studies, single-arm trials, case reports, observational stu dies, and abstracts. The quality of study was assessed using the Cochrane Risk of Bias Tool (RoB 2.0). 6 Statistical analyses were performed using Revman 5.4, using mean difference (MD) and 95% confidence intervals (CI). We analyzed dichotomous outcomes, using both risk ratios (RR) and odds ratios (OR) with 95% CI to provide a comprehensive assessment of treatment effects. Two RCTs meeting the predefined inclusion criteria were included in qualitative and quantitative analyses. 3,4 These RCTs reported data from 396 patients with active proliferative lupus nephritis (obinutuzumab =198 patients, placebo = 198 patients).

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High Performance Liquid Chromatography Determination of Fatty Acids in Drying Oils Following Lipase Action

(Abstract not found)

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The best interests of the child in the case law of the Court of Justice of the European Union

The principle that 'in all actions relating to children (…) the child's best interests must be a primary consideration' (Article 24(2) EU Charter of Fundamental Rights) is widely applied by the Court of Justice of the European Union (CJEU). This article considers preliminary rulings in which the CJEU had recourse to the best interests of the child as the criterion for settling the dispute in the main proceeding. For analytical purposes, these cases may be grouped in two clusters: cases resembling child custody disputes, and other cases. It is argued that, in the light of the varied factual circumstances of the judicial disputes, the application of the criterion of best interests of the child as primary consideration warrants further scrutiny. To this end, this arti cle identifies and assesses a practical and a conceptual challenge to the widespread application of the criterion. The former posits that the criterion is indeterminate, and this article considers whether drawing from Article 3 of the Convention on the Right of the Child may help in solving the uncertainty; the latter maintains that the test is unjust and self-defying, a critique that this article finds only partially founded, for cases resembling child custody disputes. Keywords Best interests of the child, EU law, EU Charter of Fundamental Rights, Court of Justice of the European Union, family law 1. Introduction The primacy of the interests of the child is 'one of the principles permeating the EU legal order

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